Quick Links
Resources
About MyLeukemiaTeam
Powered By
A wide variety of treatment options are used to fight leukemia. Which treatments your doctor will recommend depends largely on which type of leukemia you have. Some treatments may be combined in a treatment plan, while others may be used alone as a single treatment, also known as monotherapy. The goals of leukemia treatment can also differ. While there are treatments that can provide a cure for many cases of acute leukemia, the goal in treating chronic leukemia may be to achieve remission and prevent relapses or simply to slow cancer growth.
This article will cover the major categories of treatments used in leukemia and the basics of how they work to fight cancer. Each treatment category will have examples of situations when the leukemia treatment may be recommended.
More than 50 different drugs are used to treat blood cancers, which include leukemia, lymphoma, myeloma, and myeloproliferative neoplasms (MPNs). With so many different types of leukemia treatments available, what leads your doctor to recommend one option over another? Many factors influence which treatments are considered good options for you. Here are some of the most important factors.
The four main types of leukemia are:
Each of these types has many subtypes, and some are also classified by stage. ALL and AML are acute forms of leukemia, which grow rapidly and require immediate treatment. CLL/SLL and CML are chronic forms of leukemia, which in most cases are slow-growing and may not require treatment right away.
Types of leukemia are categorized by which kind of white blood cell is involved. Genetic details about your cancer cells may also be important for treatment decisions. Not every treatment works well for every type of leukemia.
Your age and your general health can both be risk factors in treatment for leukemia. Some treatments have possible side effects that may be considered too risky for older adults or people living with other health conditions.
Your oncologist will also consider:
For instance, is it more important to you to live as long as possible or to maintain a high quality of life with few side effects from treatment? Is it your top priority to use the most effective treatment or to avoid the risk for serious side effects? Do you plan to have children in the future? These and other considerations should be weighed in discussion with your doctor about your cancer care.
The best treatment plan for you will be the one you and your doctor agree together is your best option.
Treatment for leukemia may be given at different points for different purposes. These phases of leukemia treatment may include induction therapy, consolidation therapy, and maintenance therapy.
In acute forms of leukemia (ALL and AML), chemotherapy is often used as an initial treatment to kill as many cancer cells as possible and wipe out all signs of disease, resulting in remission.
The goal of consolidation therapy, also known as post-remission therapy, is to destroy any remaining cancer cells and make sure leukemia will not relapse. Consolidation may include chemotherapy or a stem cell transplant.
In some cases, doctors may recommend taking one or more medications long term — for years — after the induction and consolidation phases of leukemia treatment are complete. The goal of maintenance therapy is to prolong remission and prevent a relapse of leukemia.
Depending on your type of leukemia and other factors, you may use several types of treatment — either alone or in combination — at different times over the course of your cancer treatment.
Chemotherapy works by directly killing or damaging rapidly dividing cells, including cancer cells, in your body. These potent drugs must be toxic to kill cancer cells, but they can also damage healthy cells.
Depending on which drugs are involved, chemotherapy may be administered intravenously (through a vein), injected into the skin or muscle, or taken orally as pills or capsules. Some chemotherapy may be taken at home. Other types may require travel to a cancer treatment center to receive each dose or a hospital stay for the duration of a treatment cycle, which may last weeks.
There are many classes of chemotherapy drugs, including alkylating agents, antitumor antibiotics, and antimetabolites. Most chemotherapy drugs work by interfering with the DNA of cancer cells, preventing them from growing or causing them to die. Chemotherapy drugs are often combined into regimens.
Targeted therapy works by interfering with specific genes or proteins cancer cells need to grow and survive. There are many classes of targeted therapy drugs that operate in different ways, making them effective for different types of leukemia. Targeted therapies only work on cancer cells that carry their specific target. Major classes of targeted therapies for leukemia are described below.
Tyrosine kinase inhibitors (TKIs) target a protein called the BCR-ABL tyrosine kinase enzyme, which is necessary for leukemia cells in some types of leukemia to survive. TKIs used to treat CML and ALL with the Philadelphia chromosome include:
Bruton’s tyrosine kinase (BTK) inhibitors block the activity of a certain type of tyrosine kinase that cancer cells need to grow and stay alive. BTK inhibitors are used to treat CLL/SLL and some types of non-Hodgkin lymphoma, a type of blood cancer closely related to leukemia. The BTK inhibitors currently used are:
Venetoclax (Venclexta) is used to treat some cases of AML and CLL/SLL. Venclexta’s target is BCL-2, a protein that enables the survival of leukemic cells.
PI3K-delta is a kinase protein that cancer cells need to signal and control growth. PI3K inhibitors work by blocking this protein in cases of CLL/SLL. PI3K inhibitors include:
In some cases of AML, cancer cells have a mutation in a gene called FLT3. FLT3 inhibitors used to treat AML with the FLT3 mutation include:
In AML that involves genetic mutations of the IDH genes (IDH1 or IDH2), IDH inhibitors can work by making sure white blood cells mature normally into healthy cells rather than cancer cells. IDH inhibitors include:
Menin inhibitors, like revumenib (Revuforj), are a newer class of targeted therapies specifically designed for cases of acute leukemia with a lysine methyltransferase 2A (KMT2A) gene translocation. The drug treats KMT2A-related acute leukemias by blocking the connection between menin, a protein that helps control cell growth, and other proteins made by the KMT2A gene. This stops cancer cells from growing and spreading.
Immunotherapy is an approach to treating leukemia that modifies your immune system to be better at targeting and destroying cancer cells. There are different types of immunotherapy that work with different aspects of the immune system.
Some sources consider monoclonal antibodies a type of targeted therapy, while others describe these biologic drugs as a type of immunotherapy. Antibodies are proteins made by the immune system that can target genes and proteins found only on the type of white blood cell involved in leukemia. Monoclonal antibodies are synthetic versions of these proteins made in laboratories. The monoclonal antibody rituximab is used to treat certain cases of ALL and CLL, often in combination with other drugs.
Monoclonal antibodies can also be attached to another drug to create an antibody-drug conjugate. Antibody-drug conjugates use the antibody to deliver the drug directly to its target on cancer cells. Antibody-drug conjugates used in leukemia include:
Bispecific T-cell engagers, or BiTEs, have two parts. One part binds to a cancer cell, and the other binds to a T cell. T cells are immune cells that can kill cancer cells. The two parts of a BiTE allow the drug to find and attack cancer cells.
Two bispecific T-cell engagers used to treat leukemia are:
Chimeric antigen receptor (CAR) T-cell therapy works by modifying your own T cells to seek out and destroy the type of cells involved in leukemia. First, your T cells are harvested in a process similar to donating blood. Next, your T cells are shipped to a lab, where they’re genetically modified to recognize and attack a certain receptor found on your cancer cells. Finally, the modified T cells are infused back into your body.
CAR T-cell therapies approved by the U.S. Food and Drug Administration (FDA) include:
Obecabtagene autoleucel (Aucatzyl), approved for adults with relapsed or refractory B-cell precursor ALL
Hematopoietic stem cell transplants (formerly called bone marrow transplantation) are sometimes used to treat people with leukemia. Stem cell transplants can help compensate for higher doses of chemotherapy that will destroy bone marrow. The transplanted stem cells will form healthy bone marrow, replacing the destroyed cells after chemotherapy (and sometimes radiation therapy) is complete. In some people, stem cell transplantation can help cure leukemia. Not everyone with leukemia is eligible to receive stem cell therapy.
In allogeneic stem cell transplant, stem cells are harvested from the blood of a donor who may be a sibling or other close blood relative of the recipient or an unrelated person who is a good genetic match. Less commonly, an autologous stem cell transplant may be considered. In an autologous stem cell transplant, the stem cells are harvested from the person’s own blood.
Radiation therapy (also known as radiotherapy) is not a common treatment in most cases of leukemia. However, radiation therapy may be used in certain situations in some cases of ALL, AML, CLL/SLL, and CML. Radiation may be used with chemotherapy to destroy bone marrow before receiving a stem cell transplant.
Radiation interferes with cell division. Since cancer cells divide much more rapidly than normal cells, they are more vulnerable to radiation. Radiation kills cancer cells, but the normal, healthy cells of your body are better able to survive and heal.
Some people with leukemia participate in clinical trials. Clinical trials contribute to cancer research and may provide access to new treatments for leukemia not yet available to everyone. It is important to know that participants in clinical trials are protected by the process of informed consent, which ensures that all potential risks and benefits are transparent before you decide to join a trial. Participants in clinical trials can withdraw at any time.
Some chronic forms of leukemia, including many cases of CLL/SLL, may not require treatment right away. Instead, doctors may recommend a “watch-and-wait” approach, also known as watchful waiting. During watch and wait (also called watchful waiting), you will be closely monitored by your doctor with regular appointments and blood tests. Watchful waiting may last for years until some signs or symptoms indicate cancer is beginning to grow more rapidly.
Whether or not you’re actively treating your leukemia, making changes to improve your overall health can help you have a better quality of life and may even increase your treatment options for leukemia. Good nutrition and regular exercise can improve your energy and mood and help you recover faster from treatment or illness. If you smoke cigarettes, quitting smoking may help you live longer, reduce side effects and complications from cancer treatment, and help you recover faster from the effects of treatment.
More effective treatments for leukemia have increased survival rates and rates of remission over the past 10 years. Whether a case of leukemia is curable or not depends on many factors. Your health care team can best advise you on the most effective treatment to try to achieve long-term remission.
MyLeukemiaTeam is the social network for people living with leukemia. On MyLeukemiaTeam, more than 19,000 members come together to offer advice, lend support, and share their stories.
What treatments for leukemia have been helpful for you? Do you have questions for others about treatments you’re considering? Comment below, or start a conversation on your Activities page.
Get updates directly to your inbox.
But What Do They Do When One Alson Has GCA With CLL? They Give Prednison Which Increases The Lymphocytes. Help!
What Happens When One Is Allergic To Steroids And Would Treatment Start At Stage 3 Or 4?
When An Oncologist Is Doing Watchful Waiting. What Is A Ballpark Figure On How High Does The WBC Usually Climb Before He Begins Treatment.
What Treatments Help CLL Patients With Unmutated IgVH, Increased LDH And Beta2microglobulin?
Fatima Sharif, MBBS, FCPS
graduated from Aga Khan University, Pakistan, in 2017 after completing medical school.
Learn more about her here.
Kelly Crumrin
is a senior editor at MyHealthTeam and leads the creation of content that educates and empowers people with chronic illnesses.
Learn more about her here.
Michelle Collins, Ph.D.
is a freelance science writer with over 25 years of experience in pharmaceutical research and development.
Learn more about her here.
Become a member to get even more:
Your Privacy Choices
A MyLeukemiaTeam Subscriber
I have CLL. Have been taking Brukinsa for about 14 months. Am 81. Active. Practicing law full time. Feel pretty darn good. My issue? Night Sweats!! 1/2 per night. T-shirt and underwear have to be… read more
We'd love to hear from you! Please share your name and email to post and read comments.
You'll also get the latest articles directly to your inbox.