An allogeneic (donor) stem cell transplant for leukemia involves the following key points:

- Definition: Stem cells are harvested from a donor who may be a sibling, other close blood relative, or an unrelated person who is a good genetic match
- Purpose:
- Compensation for Chemotherapy: To replace bone marrow destroyed Show Full Answer

An allogeneic (donor) stem cell transplant for leukemia involves the following key points:

- Definition: Stem cells are harvested from a donor who may be a sibling, other close blood relative, or an unrelated person who is a good genetic match.
- Purpose:
- Compensation for Chemotherapy: To replace bone marrow destroyed by high doses of chemotherapy.
- Graft-Versus-Leukemia Effect: Transplanted cells help attack cancer cells.
- Eligibility: Generally for those who are otherwise healthy, have failed other treatments, and have a closely matched donor. Age limits may apply.
- Risks: Significant risk of life-threatening side effects, requiring careful consideration of benefits versus risks.
- Procedure:
- Conditioning Treatment: High-dose chemotherapy and sometimes radiation therapy to prepare the body.
- Stem Cell Collection: Donor's blood is processed to collect stem cells, which can be frozen for future use.
- Transplantation: Donor stem cells are injected into the recipient via a catheter.
- Outcomes:
- Cure Potential: Can cure leukemia in some cases.
- Survival Rates: Vary by leukemia type and phase. For example, 90% of chronic-phase CML patients are disease-free at five years.
- Post-Transplant Care: Maintenance medications and possibly hematopoietic growth factors to sustain treatment response.

This procedure is used to treat various types of leukemia, including ALL, AML, CML, CMML, and JMML, but is less commonly recommended for CLL.

 This AI-generated response comes from MyLeukemiaTeam and other selected sources. It is not a substitute for medical advice. Always ask your doctor about specific health concerns.

Allogeneic (donor) stem cell transplant for Leukemia | MyLeukemiaTeam

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