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Real members of MyLeukemiaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Treatment For Tp53 And Asxl

A MyLeukemiaTeam Member asked a question 💭
Henderson, NV

Husband is out of remission, 77 elected no bmt. Cannot take onureg. Anyone have same mutations, if so what is your treatment thx

June 24, 2023
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A MyLeukemiaTeam Member

He had Multiple myeloma, 2018 sct, remission til Sept 2022 crossed over to AML TP53, ASXL1. His induction was Decitabine 5days with venetoclax 28days. In remission for 7mbyth. For maintenance he was to take onureg but the meds caused labs to drop too much. Currently only doing blood and platelets when necessary. We are with City of hope in California we live in Nevada. They also gave same info regarding transplant. My husband declined any consideration. We r hoping he will qualify for a clinical trial, but have little to share on that at this time. If interested I will keep you informed. I will research your treatment. After going out of remission, he is on palliative care, his prognoses is not good, but
Hope treatment is successful.

July 4, 2023
A MyLeukemiaTeam Member

am 78 and MD Anderson said risk was too high for transplant due to age and than transplant success rate for TP53 is only 25% aside from age factor. Treatment plan is to start Invoqi ( chemo) . My concern is that this may only be effective for say 2 years , plus or minus.

what treatment did your husband undergo for remission ,

July 4, 2023

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