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Real members of MyLeukemiaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Has Anyone With CLL Used Venetoclax And Has Mutated TP53?

A MyLeukemiaTeam Member asked a question πŸ’­
East Lyme, CT
January 31, 2024
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A MyLeukemiaTeam Member

I have not had that type of testing, so I don't know the answer. Hopefully someone can answer your question. I have CLL but it is the slow growing kind and I am still in watch and wait, so I have not had any other tests, nor do want to have a bone marrow biopsy, at least not until it is really needed

April 27, 2024
A MyLeukemiaTeam Member

I just started Calquence with mild side effects. Venetoclax with IV infusion was an option but more logistically complicated and more visits to the hospital. I live almost 1.5 hours away so I chose the Oral Chemotherapy. I can't recall my genetic tests results of TP53 and IGHV. I do know one was mutated and one was not. Doesn't really matter based on video I found when using targeted treatment.

February 1, 2024
A MyLeukemiaTeam Member

Thanks for replying I have TP53 mutated, IGVH unmutated with 11q deletion, all three of which are not good prognostically. I am on on Venetoclax right now, we are discussing adding the Obinituzimab to it if I am not in remission next time I go. Been on V since 8/22

February 1, 2024

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